
The question Belvedere’s research-oriented residents ask about whole body cryotherapy is the right one: at what temperature does the cold-shock protein response fully activate, and how does that differ from cold water immersion? The answer: HSP70 and HSP90 induction is significantly greater at the extreme temperatures of whole body cryotherapy (-110°C to -160°C) than at cold plunge temperatures (50–59°F), because the rate of skin temperature drop at cryotherapy temperatures is faster and more complete than water immersion can produce. The systemic anti-inflammatory cytokine response is also broader, and the activation of brown adipose tissue thermogenesis is more significant because the thermal demand of the cryo room session is greater per unit time. For Marin residents who have already adopted cold plunge and want to understand what comes next in the cold exposure protocol, the cryo room is the clinical answer.